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Relationship of lithium concentrations in the brain measured by lithium-7 magnetic resonance spectroscopy to treatment response in mania.
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1994
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NeuropsychologyPsychopharmacologyNeuropsychiatryEpilepsyLithium ConcentrationsSocial SciencesNeurologyLithium ConcentrationPsychiatryTreatment ResponseDepressionNeuropharmacologyPsychiatric DisorderMood SpectrumNeurophysiologySchizophreniaMood DisordersNeuroscienceBiological PsychiatryLithium TreatmentMedicinePsychopathologyBipolar Disorder
Lithium concentrations in the brain were measured in 14 manic patients with bipolar disorder (12 with bipolar disorder, manic, and 2 with bipolar disorder, not otherwise specified, by DSM-III-R) by the use of lithium-7 magnetic resonance spectroscopy ([7Li]MRS). The reduction of Petterson Mania Rating Scale 4 weeks after the initiation of lithium treatment was not significantly correlated with concentrations in serum (r = 0.33), but was correlated with concentrations in the brain (r = 0.64; p < 0.05). These results suggest that the treatment response to lithium in manic patients with bipolar disorder is more closely related to the lithium concentration in the brain as measured by [7Li]MRS than to the concentration in serum.