Concepedia

Mechanism and free energy profile of base-catalyzed Knoevenagel condensation reaction

Ellen V. Dalessandro, Hugo P. Collin, Marcelo Siqueira Valle, Josefredo R. Pliego

RSC Advances · 2016 · 36 citations · 45 references

DOI

Concepts

Abstract

A reliable theoretical calculation of the free energy profile of a base-catalyzed Knoevenagel reaction shows that hydroxide ion elimination step is rate determining.

References

45

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Frank Neese · Wiley Interdisciplinary Reviews Computational Molecular Science · 2011 · 12.5K citations

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