Novel technetium (III)-Q complexes for functional imaging of multidrug resistance (MDR1) P-glycoprotein. - Concepedia

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Novel technetium (III)-Q complexes for functional imaging of multidrug resistance (MDR1) P-glycoprotein.

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1998

Year

Carolyn L. Crankshaw, Mary E. Marmion, Gary D. Luker, V. Venkat Rao, Julie L. Dahlheimer, B. Daniel Burleigh, Elizabeth Webb, Karen Deutsch, David Piwnica‐Worms

Abstract

Technetium-99m-Q57, 99mTc-Q58 and 99mTc-Q63 are avid transport substrates recognized by the human MDR1 Pgp, and have enhanced in vitro properties that may enable functional imaging of Pgp in vivo with improved signal-to-noise ratios and tissue contrast compared to currently available agents.