Clinical Science · 1986 · 15 citations · 0 references
Life SciencesBiochemistryPhysiologyCalcium HomeostasisCell SignalingSignal TransductionCalcium MetabolismCalcium SignalingIntracellular Calcium SignalingPlatelet ActivationPlatelet PhysiologyBlood PressureCa2+ SignalingCalcium Ion SignalingCalcium-mediated SignalingFluorescent LabelingFluorescent ProbesPlatelet Calcium MobilizationSystolic Blood Pressure
The cytoplasmic free calcium concentration ([Ca2+]i) in the platelets of spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY), deoxycorticosterone-salt hypertensive rats (DOC) and normotensive Sprague-Dawley rats (SD) was measured with the fluorescent dye, quin-2-tetra-acetoxymethyl ester. No significant difference in platelet [Ca2+]i was found between SHR and WKY or between DOC and SD rats. No correlations were found between systolic blood pressure and [Ca2+]i. These results suggest that the elevation of platelet [Ca2+]i does not necessarily accompany hypertension in rats.