Anticancer and Anti-Inflammatory Activity of Probiotic Lactococcus lactis NK34

Abstract

Lactococcus lactis is used as a fermentation starter in dairy or fermented foods and is a generally recognized as safe microorganism. Recently, probiotic L. lactis strains were reported to possess potential antipathogenic activity and suggested as functional foods for humans or additive to animal feed Probiotics are used to improve the intestinal microbiota balance. The intestinal microbiota has been reported to play a fundamental role in maintaining immune homeostasis Immunity describes the state of having sufficient biological defenses to avoid infection, disease, or other unwanted biological invasion. Innate immunity is the natural resistance that provides resistance through several physical, chemical, and cellular approaches. Subsequent general defenses include secretion of chemical signals (cytokines) and antimicrobial substances, fever, and phagocytic activity associated with inflammatory responses. Through these approaches, innate immunity can prevent the colonization of pathogenic bacteria and the proliferation of cancer cells.