Isolation of the Plant Hormone (+)-Abscisic acid as an Antimycobacterial Constituent of the Medicinal Plant Endophyte <i>Nigrospora</i> sp

Abstract

An extract of the endophytic fungus Nigropsora sp. (isolate TC2-054) from the Canadian medicinal plant Fragaria virginiana exhibited significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra. Bioassay guided fractionation revealed that linoleic acid derivatives and the plant hormone (+)-abscisic acid (ABA) were responsible for the observed antimycobacterial activity. This activity of ABA has not been previously reported.