Prostaglandins and reproduction.

Abstract

Evidence of the roles of prostaglandins (PGs) in reproductive events is accumulating. PGs have been implicated in sperm and ovum transport demise of corpus luteum function and initiation of parturition. Major species differences have been documented. Relative potencies of PGE and PGF types and sensitivity of the corpus luteum to PG-induced luteolysis have been shown to differ by species. For example rhesus monkeys show a luteolytic effect when PGF2 alpha is administered in late luteal phase of nonpregnant animals. PG treatment was associated with decreased ovarian and uterine blood flow as well indicating vascular involvement may be associated with PG mechanism of action. These results along with results of studies measuring uterine contractility and rates of metabolism in peripheral circulation indicate preferential uptake and retention of PGs by different tissues in vivo; recent research has reported the presence of PG receptors in tissues supporting the theory of preferential uptake and retention.