PubMed · 2009 · 16 citations · 0 references
Public HealthMaternal HealthOncologyHigh-risk PregnancyInfant HealthPerinatal EpidemiologyCancer RiskHepatobiliary CancerHepatobiliary DiseaseLow Birth Weight EpidemiologyMaternal SmokingPerinatal Risk FactorsLogistic Regression AnalysisMaternal Age EffectsMaternal Cigarette SmokingMaternal Smoking ExposurePerinatal Risk StratificationPrenatal Tobacco ExposureSmoking History In PregnancyTobacco Use Among Pregnant Women
OBJECTIVE: To explore the risk factors for hepatoblastoma. METHODS: A case-cohort study using Logistic regression multiple variables analysis of medical record data sets was conducted to examine infant and perinatal risk factors for hepatoblastoma. RESULTS: Birth weight less than 1,000 g was associated with a strongly increased risk of hepatoblastoma (odds risk, OR = 26.0, 95% confidence interval, CI: 14.0 to 65.7). After adjustment of birth weight, a moderately increased risk of hepatoblastoma was found for older maternal age ( > 35 years vs. 20 to 34 years: OR = 2.6, 95% CI: 0.9 to 5.9), maternal smoking (OR = 2.9, 95% CI: 1.1 to 4.2) and higher maternal pregnancy body mass index (OR = 3.2, 95% CI: 1.0 to 6.7). CONCLUSION: Very low birth weight and maternal characteristics including overweight, smoking are associated with hepatoblastoma risk.