PubMed · 1971 · 59 citations · 18 references
Life SciencesBiochemistryMicrobiologyMedical MicrobiologyMicrobial PathogenesisMicrobial PhysiologyExtrinsic Factors Affecting Microbial GrowthIntrinsic Factors Affecting Microbial GrowthIron HomeostasisIron MetabolismIron NutritionIron TransportBinding CapacityCellular Iron UptakeComplement-mediated Bacterial KillingEscherichia ColiIron InteractionsMicrobial Iron AcquisitionNatural Antibody ResponsesTransferrin-mediated Iron Transport
Iron in excess of the binding capacity of transferrin allows Escherichia coli to grow in fresh serum. This appears to be due to two mechanisms. Firstly iron stimulates growth as it is an essential metabolite which is not available to E. coli in serum. Secondly, it interferes with bacterial killing, a process normally mediated by natural antibody and complement.
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Lysis of gram-negative organisms and the role of versene
Roy Repaske · Biochimica et Biophysica Acta · 1958 · 279 citations