Treatment of melanoma in-transit metastases confined to the limb

An endotoxin-induced serum factor that causes necrosis of tumors.

E A Carswell, Lloyd J. Old, Robert Kassel et al. · Proceedings of the National Academy of Sciences · 1975 · 4.5K citations · Full text

Veterinary Medicine, Immunology, Pathobiology +15

Chemotherapy of Cancer

Oscar Creech, Edward T. Krementz, Robert F. Ryan et al. · Annals of Surgery · 1958 · 883 citations · Full text

Medicine, Oncology, Pharmacotherapy +10

High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma.

D Liénard, Patricia Ewalenko, Jean-Baptiste Delmotte et al. · Journal of Clinical Oncology · 1992 · 723 citations

Pharmacy, Oncology, Pharmacotherapy +17

Dosimetry in isolation perfusion of the limbs by assessment of perfused tissue volume and grading of toxic tissue reactions

J Wieberdink, C. Benckhuysen, R. P. Braat et al. · European Journal of Cancer and Clinical Oncology · 1982 · 458 citations

Medicine, Pharmacology, Toxicology +14

Recombinant Human Tumor Necrosis Factor Administered as a 24-Hour Intravenous Infusion. A Phase I and Pharmacologic Study

D R Spriggs, Matthew L. Sherman, H. R. Michie et al. · JNCI Journal of the National Cancer Institute · 1988 · 309 citations

Medicine, Pharmacokinetics, Pharmacology +12