MedicinePharmacologyPhysiologyExperimental PharmacologyNeuropharmacologyPharmacodynamicsCardiovascular PharmacodynamicsCardiovascular PharmacologyMedicinal PlantsStimulant PlantsCardiovascular BiologyConcentrationVasoactive Drug MechanismsVasopressor PharmacodynamicsVasopressor Pharmacology
Skimmianine, a general component contained in the plants of Rutaceae, was found to have a selective inhibitory effect on the 5-hydroxytryptamine-induced vasopressor responses of rats. A similar inhibitory action was also observed in the isolated atria. Moreover, skimmianine produced a nonspecific blockade of the cardiovascular functions at higher concentration.