Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14. - Concepedia

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Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.

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2002

Year

Espen B. Ellingsen, Siegfried Morath, Trude Helen Flo, Andra B. Schromm, Thomas Härtung, Christoph Thiemermann, Terje Espevik, Douglas T. Golenbock, Daniel J. Foster, Rigmor Solberg,

Abstract

We propose that (i) LTA from S. aureus triggers the release of cytokines during staphylococcal infections, and (ii) both monocytes and T cells contribute to cytokine production induced by LTA. TLR2 may mediate cellular activation by LTA, but the functional significance of this receptor during staphylococcal infections remains elusive.