Reaccumulation of globotriaosylceramide in podocytes after agalsidase dose reduction in young Fabry patients

Abstract

Partial clearance, reaccumulation and renewed partial clearance of podocyte GL3 deposits in serial kidney biopsies over 8-10 years were seen in parallel with agalsidase dose adjustments. Repeated kidney biopsies may impact therapeutic choices in Fabry disease.