Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma

Abstract

AFP and MDK have a complementary role in HCC detection. MDK increases the diagnostic yield in AFP-negative HCC and has greater diagnostic performance than AFP, OPN and DKK-1 in the diagnosis of NASH-HCC. Additionally, MDK has a promising role in the pre-clinical diagnosis of HCC.