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Primary malignant lymphoma of the uterine corpus and cervix. Report of a case with immunocytochemical analysis.
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1989
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ImmunologyPathologyGynecologyImmunophenotypingGynecology OncologyCarcinomaOvarian CancerOncologySurgical PathologyUterine CorpusPublic HealthMalignant LymphomaPrimary Malignant LymphomaLymphoid NeoplasiaHistopathologyMalignant DiseaseMalignant CellsUterine LymphomaCervical CancerImmunocytochemical AnalysisLymphatic DiseaseMedicineCytopathology
In a 69-year-old woman, a gynecologic smear was the first indication of the presence of a nonepithelial malignant tumor. While first thought to represent an adenocarcinoma, malignant lymphoma was later cytologically suspected because of the presence of isolated large malignant cells with macronucleoli. The initial clinical and histologic studies failed to indicate a malignancy. The malignant cells in postoperative tissue samples showed a positive immunohistochemical reaction for leukocyte-common antigen (LCA) and a negative reaction for epithelial membrane antigen, confirming the cytologic suggestion of a uterine lymphoma. Immunocytochemical staining subsequently performed on the destained cytologic specimen gave a positive immunoreactivity to LCA in the cytoplasm of the malignant cells.