Down-regulation of the IGF-1 system parallels the attenuation in the proliferative capacity of rat ventricular myocytes during postnatal development. - Concepedia

Concepedia

Publication | Closed Access

Down-regulation of the IGF-1 system parallels the attenuation in the proliferative capacity of rat ventricular myocytes during postnatal development.

50

Citations

0

References

1995

Year

Wei Cheng, Krzysztof Reiss, Jan Kajstura, Krzysztof Kowal, Federico Quaini, Piero Anversa

Abstract

In conclusion, the decline in myocyte proliferation with cardiac development appears to be coupled with attenuation of the IGF-1-IGF-1R system, which may condition the changes in late growth-regulated genes, DNA replication, and cellular mitotic division in the myocardium.