The perfusion of the adrenal gland with reference to the mechanism of adrenaline stabilisation

Abstract

AN investigation of the physiological properties of the Ringer-Locke perfusate of the adrenal gland by Schkawera and Kusnetzow [1923] revealed the presence of a sympathomimetic substance which is remarkably resistant to oxidation but in all other respects behaves as adrenaline; they concluded that a stable "adrenaline-like" substance, possibly a precursor of the hormone, is secreted on perfusion. More recently evidence was adduced [Heard and It was found that perfusion of