PubMed · 1978 · 13 citations · 0 references
PharmacyBiochemistryToxicologyBiochemical ToxicologyHepatotoxicologyMechanisms Of ToxicityChemical-induced HepatotoxicityHepatic ToxicityHepatotoxicity MechanismsLipid MetabolismLipid PeroxidationMechanisms Of Toxic InjuryCarbon Dioxide ActivationCarbon Tetrachloride HepatotoxicityCarbon Tetrachloride ToxicityLipid Peroxidation In HepatotoxicityLiver Injury ResponseLiver Toxicity MechanismsMouse Liver MicrosomesRat Liver Microsomes
Males from three different strains of mice (GXF; CF1, and Swiss) were compared in their liver response to CCl4 effects. They were capable to intensively activate CCl4 to .CCl3. No CCl4 induced lipid peroxidation was detected in the liver microsomes from any of them. All the strains remakably responded to the CCl4 induced liver damage. Results further strengthen our previous hypothesis that covalent binding of CCl4 reactive metabolites to cellular constituents is more important in relation to liver cell injury than early changes in lipid peroxidation.