Immunochemical studies of organ and tumor lipids: VIII. comparison of human tumor and ox spleen cytosides

Abstract

Preparations of cytolipin H, a human tissue lipid hapten containing fatty acid, sphingosine, glucose, and galactose in equimolar proportions (cytoside), have been compared with preparations of similar composition isolated from ox spleen. The iodine number and the specific rotation of preparations derived from human tumor are significantly larger than those from ox spleen. Results of other chemical analyses (based on the carbohydrate and sphingosine portions of the molecule) as well as immunochemical reactions are indistinguishable for both.