Concepedia

FGFR3 and TP53 mutations in a prospective cohort of Belarusian bladder cancer patients.

Smal Mp, A.I. Rolevich, Polyakov Sl, Krasny Sa, Goncharova Ri

PubMed · 2014 · 12 citations · 13 references

Abstract

Our findings confirm the alternative role of FGFR3 and TP53 mutations in the development of bladder cancer. Together these two genetic markers are attributed to 62% of the tumors studied. Tumors with both wild type genes included urothelial carcinomas of all stages and grades and may develop through another genetic pathway. To elucidate complete molecular profile of bladder tumors further additional studies are needed.

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13

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Nature · 2013 · 9.9K citations · Full text

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Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

Guangwu Guo, Xiaojuan Sun, Chao Chen et al. · Nature Genetics · 2013 · 504 citations · Full text

Molecular Grading of Urothelial Cell Carcinoma With Fibroblast Growth Factor Receptor 3 and MIB-1 is Superior to Pathologic Grade for the Prediction of Clinical Outcome

Bas W.G. van Rhijn, André N. Vis, Theodorus van der Kwast et al. · Journal of Clinical Oncology · 2003 · 319 citations

Combined Gene Expression and Genomic Profiling Define Two Intrinsic Molecular Subtypes of Urothelial Carcinoma and Gene Signatures for Molecular Grading and Outcome

David Lindgren, Attila Frigyesi, Sigurður Guðjónsson et al. · Cancer Research · 2010 · 306 citations