Multicentric reticulohistiocytosis: a case with enhanced interleukin-1, prostaglandin E2 and interleukin-2 secretion.

Abstract

We describe a 47-year-old woman with multicentric reticulohistiocytosis. While the disease was in remission without therapy, interleukin-1 and prostaglandin E2 secretions by adherent cells was increased as well as interleukin-2 secretion by peripheral mononuclear cells. This suggests that macrophages play an essential role in the pathogenesis of this disease.