Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD

Abstract

Key Points Peri-alloHCT IL-33 delivery prevents acute GVHD through MAPK-dependent expansion of radiation-resistant recipient ST2+ Tregs. IL-33–expanded Tregs regulate myeloid cell differentiation and activation, and limit effector T-cell accumulation in GVHD-target tissue.