Apelin-APJ effects of ginsenoside-Rb1 depending on hypoxia-induced factor 1α in hypoxia neonatal cardiomyocytes

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations · Full text

Genetics, Molecular Biology, Hif-1 Subunits +21

Inhibition of Extracellular Signal–Regulated Kinase Enhances Ischemia/Reoxygenation–Induced Apoptosis in Cultured Cardiac Myocytes and Exaggerates Reperfusion Injury in Isolated Perfused Heart

Tianli Yue, Chuanlin Wang, Juan-Li Gu et al. · Circulation Research · 2000 · 418 citations

Cardiac Muscle, Heart Failure, Apoptosis +20

Novel Role for the Potent Endogenous Inotrope Apelin in Human Cardiac Dysfunction

Mary M. Chen, Euan A. Ashley, David Deng et al. · Circulation · 2003 · 345 citations

Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells

Matthias J. Kleinz, Jeremy N. Skepper, Anthony P. Davenport · Regulatory Peptides · 2004 · 284 citations · Full text

Inflammation, Signal Transduction, Angiogenesis +10

Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells

Matthias J. Kleinz, Anthony P. Davenport · Regulatory Peptides · 2003 · 284 citations

Inflammation, Angiogenesis, Human Vascular +10