Activation of Plasma Thromboplastinogen and Evidence of an Inhibitor.

Abstract

The first step in coagulation is the conversion of thromboplastinogen to active thromplastin by a platelet factor. The platelets from hemophilic blood react equally as well as those of normal blood. Evidence of a factor which inhibits the activation of thromboplastinogen has been found in the blood of a patient who has an acquired hemophilia-like condition.