Organic & Biomolecular Chemistry · 2016 · 22 citations · 37 references
Chemical EngineeringNovel OrganocatalystsBioorganic ChemistryEngineeringBiochemistryNatural SciencesOrganic ChemistryInteresting NCatalysisOrganocatalytic Asymmetric AdditionChemistryChiral NTrifluoromethyl KetiminesEnantioselective AdditionAsymmetric CatalysisSynthetic ChemistryEnantioselective Synthesis
A highly enantioselective addition of alcohols to cyclic trifluoromethyl ketimines is developed catalyzed by quinine-thiourea, giving biologically interesting N,O-ketals in up to 99% yield and 96% ee.
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