Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization

Nivolumab plus Ipilimumab in Advanced Melanoma

Jedd D. Wolchok, Harriet M. Kluger, Margaret K. Callahan et al. · New England Journal of Medicine · 2013 · 4.2K citations · Full text

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Restoring function in exhausted CD8 T cells during chronic viral infection

Daniel L. Barber, E. John Wherry, David Masopust et al. · Nature · 2005 · 4K citations

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela et al. · Nature · 2006 · 2.6K citations

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HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

Véronique M. Braud, David Allan, Christopher A. O'Callaghan et al. · Nature · 1998 · 2.2K citations

Life Sciences, Immunology, Molecular Biology +13

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

Kaori Sakuishi, Lionel Apétoh, Jenna M. Sullivan et al. · The Journal of Experimental Medicine · 2010 · 2.1K citations · Full text

Life Sciences, Immunology, Oncology +16