PubMed · 2003 · 43 citations · 0 references
Life SciencesBiochemistryPharmacologyFood ChemistryHepatic PharmacotherapyHepatotoxicologyAntioxidant DefenseChemical-induced HepatotoxicityHepatic ImpairmentHepatotoxicity MechanismsLipid PeroxidationLiver DiseaseAntioxidant Protection Against HepatotoxicityAntioxidant TreatmentCatalase FunctionGlutathione Peroxidase ActivityLipid Peroxidation In HepatotoxicityLipid Peroxidation MarkersPlant Extract AntioxidantsTotal Serum Bilirubin
The oral administration in varying doses of aqueous suspension of extract of L. alba, bark extract to rats for 10 days afforded good hepatoprotection against CCl4 induced elevation in serum marker enzymes, serum bilirubin, liver lipid peroxidation and reduction in total serum protein, liver glutathione, glutathione peroxidase, glutathione-s-transferase, glycogen, superoxide dismutase and catalase activity. The results suggest hepatoprotective and antioxidant activity of extract of L. alba bark.