The Journal of Immunology · 1998 · 15 citations · 28 references
Life SciencesImmunologyMolecular BiologyHost-pathogen InteractionsImmunogeneticsImmunology Of Infectious DiseasesAntigen PresentationAntigen Presentation RegulationImmune Responses To InfectionImmunopathology Of Infectious DiseasesMajor Histocompatibility ComplexClass Ii Histocompatibility AntigensHla Class Ii MoleculesInvariant Chain FunctionMajor Histocompatibility Complex Class Ii DeficiencyMajor Histocompatibility Complex Class Ii PresentationMhc Antigen PresentationMhc Class Ii DeficiencyMhc Class Ii Molecules
Abstract Antigen presentation by MHC class II (class II) is facilitated by the accessory molecules, invariant chain (Ii) and H2-M. Ii associates with class II during biosynthesis and promotes transport of class II to Ag-loading compartments. One function of H2-M is the removal of Ii fragments from MHC class II. We have previously demonstrated that Ii-deficient mice, unlike class II-deficient mice, are resistant to L. major infection. In the present study, we found that H2-M-deficient (H2-M0) mice were susceptible to progressive infection with L. major. The dispensability of Ii for control of L. major allowed genetic analysis of whether H2-M functions by association with or independently of Ii. In contrast to Ii-deficient (Ii0) mice, Ii0H2-M0 mice were as susceptible to L. major as H2-M0 mice. Thus, H2-M has an essential, Ii-independent function during presentation of microbial pathogens.
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Mice lacking MHC class II molecules
Dominic Cosgrove, David W. Gray, Andrée Dierich et al. · Cell · 1991 · 850 citations · Full text
The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3
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