A Suggested Mechanism for the Selective Procedure for Isolating Thymine-Requiring Mutants of <i>Escherichia coli</i>

Jennifer Bertino, K. A. Stacey

Biochemical Journal · 1966 · 42 citations · 8 references

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Abstract

Aminopterin, an analogue of folic acid, binds very strongly to the enzyme dihydrofolate reductase, preventing the generation of tetrahydrofolate, the cofactor of a number of Ci transfers (Huennekens,

References

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