Calcium homeostasis in 40 adolescents with beta-thalassemia major: a case-control study of the effects of intramuscular injection of a megadose of cholecalciferol.

Abstract

Vitamin D deficiency was detected in 100 % of our thalassemic adolescents. An IM injection of a mega dose of cholecalciferol is an effective therapy for treatment of hypovitaminosis D in thalassemic and non-thalassemic adolescents for 3 months but its effects do not persist for 6 months.