PubMed · 2016 · 16 citations · 0 references
Tumor BiologySurgical OncologyTumoral PathologySkin CancerMalignant DiseaseSurgical PathologyHistopathologyImmunologyPathologyMerkel Cell CarcinomaDermatologyImmunotherapyMedicineNovel PolyomavirusTumor MicroenvironmentCancer ResearchCancer-associated Virus
Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of unknown origin that usually presents in the elderly population. A novel polyomavirus has been associated with a large percentage of tumors. Immune response plays an important role in pathogenesis of MCC. This article reviews the history, pathogenesis, presentation, and treatment of MCC. Future treatments also are discussed briefly.