The E3 Ubiquitin Ligase c‐Cbl Inhibits Microglia‐Mediated <scp>CNS</scp> Inflammation by Regulating <scp>PI</scp>3K/Akt/<scp>NF</scp>‐<i>κ</i>B Pathway

Abstract

In sum, c-Cbl inhibits expression of LPS-stimulated proinflammatory cytokines and chemokines in microglia. We demonstrate an unprecedented role for c-Cbl in microglia-mediated neuroinflammation involving PI3K/Akt/NF-κB pathway.