Concepedia

Processed Panax ginseng , sun ginseng, inhibits the differentiation and proliferation of 3T3-L1 preadipocytes and fat accumulation in Caenorhabditis elegans

Hye-Jin Lee, Jinhee Kim, Jun Yeon Park, Ki Sung Kang, Joeng Hill Park, Gwi Seo Hwang

Journal of Ginseng Research · 2016 · 36 citations · 40 references

DOIFull text

Open access

Abstract

Our results suggest that SG effectively inhibits adipocyte proliferation and differentiation through the downregulation of PPARγ and C/EBPα, by suppressing Akt (Ser473) phosphorylation and enhancing NO production. These results provide strong evidence to support the development of SG for antiobesity treatment.

References

40

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Induction of Peroxisome Proliferator-Activated Receptor γ during the Conversion of 3T3 Fibroblasts into Adipocytes Is Mediated by C/EBPβ, C/EBPδ, and Glucocorticoids

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, , +17

Development of the reproductive system of Caenorhabditis elegans

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, , +9

CCAAT/enhancer-binding protein β is required for mitotic clonal expansion during adipogenesis

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Regulation of Peroxisome Proliferator-Activated Receptor γ Expression by Adipocyte Differentiation and Determination Factor 1/Sterol Regulatory Element Binding Protein 1: Implications for Adipocyte Differentiation and Metabolism

Lluís Fajas, Kristina Schoonjans, Laurent Gelman et al. · Molecular and Cellular Biology · 1999 · 450 citations · Full text