Cholesterol overload induces apoptosis in SH-SY5Y human neuroblastoma cells through the up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

Roy G. Cutler, Jeremiah Kelly, Kristin Storie et al. · Proceedings of the National Academy of Sciences · 2004 · 1.2K citations · Full text

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BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

Heidi Phillips, Jeanne M. Hains, Mark Armanini et al. · Neuron · 1991 · 924 citations

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A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

Lorenzo M. Refolo, Miguel A. Pappolla, John J. LaFrancois et al. · Neurobiology of Disease · 2001 · 520 citations · Full text

Life Sciences, Neuroscience, Pharmacology +14

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26‐week randomized, placebo‐controlled, double‐blind trial

Mikael Simons, Frank Schwärzler, Dieter Lütjohann et al. · Annals of Neurology · 2002 · 414 citations

Medicine, Pharmacology, Pharmacotherapy +12

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

Huaqi Xiong, Debbie Callaghan, Aimee Jones et al. · Neurobiology of Disease · 2007 · 273 citations · Full text

Life Sciences, Neurobiology, Neuroscience +16