PD-L1 Expression Is Associated with Tumor FOXP3⁺ Regulatory T-Cell Infiltration of Breast Cancer and Poor Prognosis of Patient

Abstract

The results suggest that PD-L1 and FOXP3(+)Tregs may work synergistically and their up-regulated expressions promote tumor immune evasion in breast cancer. Combinatorial immunotherapeutic approaches aiming on blocking PD-L1 and depleting Tregs might improve therapeutic efficacy in breast cancer patients, especially those with basal-like carcinoma.