Preliminary Observations on the Effect of Human Leukocyte Interferon in Non-Hodgkin's Lymphoma

Abstract

IN laboratory animals both endogenously induced and passively administered interferon have inhibitory effects on a wide variety of tumors, including those caused by oncogenic viruses.1 2 3 4 Such effects are most striking when the interferon is administered prophylactically, but interferon has occasionally been observed to have therapeutic effects. In the latter situation, its continued administration appears required for maintenance of the beneficial effect. Studies by Strander and his associates at the Karolinska Hospital in a variety of solid tumors, particularly osteogenic sarcoma,5 have suggested that human leukocyte interferon may have beneficial effects in man.In recent years it has also been recognized . . .