AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2

Abstract

Evidence here reveals that the rapid growth and proliferation of cancer cells lacking the tumor suppressor LKB1 is due to reduced activity of AMPK, and suggests a therapeutic approach by which this block might be circumvented. Mol Cancer Res; 14(8); 683-95. ©2016 AACR.