EFFECT OF CENTELLA ASIATICA ON MILD COGNITIVE IMPAIRMENT (MCI) AND OTHER COMMON AGE-RELATED CLINICAL PROBLEMS

Abstract

Centella asiatica is a herb used since ancient times in Ayurveda to improve cognitive functioning. The current study is aimed at managing mild cognitive impairment (MCI) and other age-related problems in elderly. MCI is a problem which may convert into Alzheimer’s disease in later stages. Although the concept of MCI is based on the presence of specific cognitive deficits, several studies show that subjects with MCI can develop depression and disruptive behaviour (e.g agitation, aggression). The present study was conducted in sixty elderly subjects of age group 65 and above with written consent, registered at the geriatric out patient clinic at S.S. Hospital, BHU. The Diagnostic tool used in this study was Mini Mental State Examination. Also, parameters like Activities of Daily Living, Instrumental Activities of Daily living and Yesavage Geriatric Depression scale were used to monitor the subjects. Centella asiatica aqueous extract was prescribed in a dose of 500mg twice a day (1000 mg daily) for 6 months. A favourable improvement was observed in MCI along with other problems like Hypertension, insomnia, loss of appetite, constipation.