DISINTEGRANT PROPERTIES OF A PARACETAMOL TABLET FORMULATION LUBRICATED WITH CO - PROCESSED LUBRICANTS

Abstract

In this study, cocoa butter co - processed with a combination of magnesium stearate and talc (CMT) was evaluated as a lubricant in a paracetamol tablet formulation. In the evaluation study the disintegrant properties - tablet disintegration time (DT) and crushing strength friability/disintegration time ratio (CSFR/DT) of paracetamol tablets prepared from granules lubricated with CMT were compared with tablets prepared from granules lubricated with combination of magnesium stearate and talc (MT) alone. The study reveals that the lubricant type and concentration influenced the disintegrant properties, and that the co - processed lubricant could be useful in situations where a low CSFR/DT ratio is required e.g. sustained release tablets. Rezumat In studiul experimental prezent s-au evaluat caracteristicile de lubrefiere ale untului de cacao co-procesat cu un amestec de stearat de magneziu si talc, in formularea comprimatelor cu paracetamol. A fost efectuat un studiu comparativ cu comprimate de paracetamol in a caror formulare s-a folosit amestecul de stearat de magneziu si talc.