Synthesis of Substituted Imidazoles via a Multi-Component Condensation Catalyzed by p-toluene Sulfonic Acid, PTSA

Abstract

A robust and reliable one pot synthetic method has been developed for 2,4,5-trisubstituted and 1,2,4,5-tetra substituted imidazoles. The synthetic sequence, via a multi-component condensation catalyzed by p-toluenesulfonic acid (PTSA), provides good isolated yields under mild conditions. The structural features have been arrived at from their micro analytical, infra red, mass and 1 H NMR spectral data. Short synthesis, mild reaction conditions, inexpensive reagents and high yield illustrate the