Use of Mannitol in Exogenous and Endogenous Intoxications

Abstract

THE use of mannitol for osmotic diuresis has largely been confined to the laboratory and has so far had only limited clinical application. Recently, however, its clinical usefulness in the diagnosis and therapy of oliguric states1 and in the prevention of acute functional renal failure2 , 3 has been emphasized. The effectiveness of mannitol in markedly augmenting urine flow has suggested its application in the treatment of acute intoxications due to endogenous and exogenous substances available for renal excretion.Osmotic diuresis was first applied therapeutically in patients with barbiturate intoxication by Ohlsson4 and subsequently by Mollaret et al.5 with urea. Lassen6 recently . . .