New England Journal of Medicine · 1980 · 166 citations · 6 references
PharmacyObstetricsToxicologyFertilityReproductive MedicineReproductive ToxicologyFemale Reproductive ToxicologyPregnancyPrenatal Risk AssessmentPrenatal ToxicityPrenatal ToxicologyReproductive RiskEpidemiologic Exposure AssessmentHormone Exposure RiskMaternal Exposure EffectsPrenatal Reproductive ToxicityRelative Risk EstimationReproductive Hormone ExposureReproductive Outcome AssessmentSubjects
Fertility and outcome of pregnancy were examined in women participating in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. We compared 618 subjects who had prenatal exposure to DES with 618 control subjects. Fertility, measured in terms of pregnancies achieved, did not differ between the women exposed to DES and the controls. An increased risk of unfavorable outcome of pregnancy was associated with DES exposure (the relative risk of any unfavorable outcome of pregnancy was 1.69; P less than 0.001). Speculation on biologic mechanisms that might produce this difference is premature, since additional data about these subjects must be collected. Among DES-exposed women who became pregnant, 81 per cent had at least one full-term live birth.
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Obtaining Confidence Intervals for the Risk Ratio in Cohort Studies
Daniela Katz, Jorge Baptista, Stanley P. Azen et al. · Biometrics · 1978 · 421 citations
FOLLOW-UP STUDY OF MALE AND FEMALE OFFSPRING OF DES-EXPOSED MOTHERS
Marluce Bibbo, William B. Gill, Freidoon Azizi et al. · Obstetrical & Gynecological Survey · 1977 · 313 citations
Prenatal Exposure to Stilbestrol
Arthur L. Herbst, David C. Poskanzer, Stanley J. Robboy et al. · New England Journal of Medicine · 1975 · 261 citations