Cutaneous Anergy and Hodgkin's Disease

Abstract

THE association of the reticuloendothelial system with immunity is well known. It is not surprising, therefore, that disturbance of this system modifies the pattern of immunity. Blockage of the reticuloendothelial system by inert particulate matter has been shown to cause a temporary depression of antibody production.1 The association of Hodgkin's disease with a negative tuberculin reaction is familiar.2 Speculation concerning the significance of this phenomenon has been centered in large part on the relation of tuberculosis to Hodgkin's disease. Much attention has been given to establishing the tubercle bacillus in an etiologic role. Sternberg,3 as early as 1898, was convinced . . .