JNCI Journal of the National Cancer Institute · 1981 · 189 citations · 0 references
MedicineImmunologyOncologyCancer ImmunologyGenitourinary OncologyTumor ImmunologyProstate CancerProstate PathologyProstate-specific Antigen TestingProstatic PathologyTumor AntigensAntiserum PreparationProstate Cancer Detection Using Prostate-specific AntigenProstatic Immune Response
Specificity of a previously reported prostate antigen (PA) was assessed by several immunologic procedures. This antigen, restricted in distribution to the prostate gland, was detected within ductal epithelial cells. Continuous established cell lines LNCaP and PC-3 of malignant prostate origin retained the expression of PA. Tumor cells released the antigen in vitro into the culture fluid and also in vivo into the circulation of nude mice preinoculated with LNCaP cells. Prostate cells in culture also specifically accreted immunoglobulin fragments of PA antiserum.