7,8‐dihydroxyflavone Ameliorates Motor Deficits Via Suppressing <i>α</i>‐synuclein Expression and Oxidative Stress in the <scp>MPTP</scp>‐induced Mouse Model of Parkinson's Disease

Abstract

Taken together, these results indicate that DHF treatment may suppress the accumulation of α-synuclein and oxidative stress via activating TrkB and subsequently block the loss of dopaminergic neurons in the SN and striatum, thereby ameliorating MPTP-induced motor deficits in the C57BL/6 mice.