Contrast Media & Molecular Imaging · 2016 · 59 citations · 61 references
MedicineMedicinal ChemistryPharmacologyBiomedical ImagingDiagnostic ImagingMolecular ImagingContrast AgentsContrast MediaMagnetic Resonance Contrast MechanismsMagnetic Resonance ImagingMolecular Probe DevelopmentRenal ImagingChemical Exchange Saturation Transfer ImagingContrastKidney PhysiologyMagnetic Resonance Imaging Contrast AgentsMolecular Imaging ProbesPh SensorsPh-sensitive ProbesSaturation Transfer Contrast
A series of intra-molecular hydrogen bonded imidazoles and related heterocyclic compounds were screened for their N-H chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) contrast properties. Of the compounds, imidazole-4,5-dicarboxamides (I45DCs) were found to provide the strongest contrast, with the contrast produced at a large chemical shift from water (7.8 ppm) and strongly dependent on pH. We have tested several probes based on this scaffold, and demonstrated that these probes could be applied for in vivo detection of kidney pH after intravenous administration. Copyright © 2016 John Wiley & Sons, Ltd.
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Pathophysiology and treatment of focal cerebral ischemia
Bo K. Siesjö · Journal of neurosurgery · 1992 · 1.3K citations
Medicine, Neurology, Neuroscience +16
Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate
Ferdia A. Gallagher, Mikko I. Kettunen, Sam E. Day et al. · Nature · 2008 · 846 citations