Staphylococcal IgE Antibodies, Hyperimmunoglobulinemia E and<i>Staphylococcus aureus</i>Infections

Abstract

IN 1966 Davis et al.1 described two girls with chronic eczema, recurrent staphylococcal infections and an abnormal inflammatory response with the formation of "cold" staphylococcal abscesses (Job's syndrome). Buckley et al.2 observed hyperimmunoglobulinemia E in two boys with severe recurrent skin and lung infections, and Clark et al.3 demonstrated depressed chemotaxis of polymorphonuclear leukocytes and hyperimmunoglobulinemia E in a girl with similar clinical manifestations. Subsequently, Hill et al.4 reported hyperimmunoglobulinemia E and defective chemotaxis of polymorphonuclear leukocytes in the two original cases of Job's syndrome. Several other patients with related disorders have recently been described.4 5 6 7 8 9 10 11 12 13 Cell-mediated immunity was abnormal in . . .