Concepedia

Food‐derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice

Noritaka Nakamichi, Keigo Nakayama, Takahiro Ishimoto, Yusuke Masuo, Tomohiko Wakayama, Hirotaka Sekiguchi, Keita Sutoh, Koji Usumi, Shoichi Iseki, Yukio Kato

Brain and Behavior · 2016 · 96 citations · 30 references

DOIFull text

Open access

Abstract

Thus, orally ingested ERGO is transported across the BBB into the brain, where it may promote neuronal differentiation and alleviate symptoms of depression at plausibly achieved level of daily ingestion.

References

30

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

Luca Santarelli, Michael Saxe, Cornelius T. Gross et al. · Science · 2003 · 4.3K citations · Full text

, , +18

Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus

Jessica E. Malberg, Amelia J. Eisch, Eric J. Nestler et al. · Journal of Neuroscience · 2000 · 3.1K citations · Full text

, , +16

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

Jason S. Snyder, Amélie Soumier, Michelle Brewer et al. · Nature · 2011 · 1.4K citations · Full text

, , +8

Discovery of the ergothioneine transporter

Dirk Gründemann, Stephanie Harlfinger, Stefan Gölz et al. · Proceedings of the National Academy of Sciences · 2005 · 576 citations · Full text

Protective Effects of Lamotrigine, Aripiprazole and Escitalopram on Depression-induced Oxidative Stress in Rat Brain

İ̇brahim Eren, Mustafa Nazıroğlu, Arif Demirdaş · Neurochemical Research · 2007 · 231 citations

, , +11