Concepedia

Association of Bax Expression and Bcl2/Bax Ratio with Clinical and Molecular Prognostic Markers in Chronic Lymphocytic Leukemia

Ksenija Vučićević, Vladimir Jakovljević, Nataša Čolović, Nataša Tos̆ić, Tatjana Kostić, Irena Glumac, Sonja Pavlović, Teodora Karan-Djurašević, Milica C̆olović

Journal of Medical Biochemistry · 2016 · 75 citations · 42 references

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Abstract

Our results suggest that dysregulated expression of <i>Bcl2</i> and <i>Bax</i>, which leads to a high <i>Bcl2/Bax</i> ratio in leukemic cells, contributes to the pathogenesis and clinical course of CLL.

References

42

Frequent deletions and down-regulation of micro- RNA genes <i>miR15</i> and <i>miR16</i> at 13q14 in chronic lymphocytic leukemia

George A. Calin, Calin Dan Dumitru, Masayoshi Shimizu et al. · Proceedings of the National Academy of Sciences · 2002 · 5K citations · Full text

<i>miR-15</i> and <i>miR-16</i> induce apoptosis by targeting BCL2

Amelia Cimmino, George A. Calin, Muller Fabbri et al. · Proceedings of the National Academy of Sciences · 2005 · 3.5K citations · Full text

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Genomic Aberrations and Survival in Chronic Lymphocytic Leukemia

Hartmut Döhner, Stephan Stilgenbauer, Axel Benner et al. · New England Journal of Medicine · 2000 · 3.3K citations

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

Terry J. Hamblin, Zadie Davis, Anne Gardiner et al. · Blood · 1999 · 2.7K citations

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia

Rajendra N. Damle, Tarun Wasil, Franco Fais et al. · Blood · 1999 · 2.6K citations