Short bowel syndrome (SBS)‐associated alterations within the gut‐liver axis evolve early and persist long‐term in the piglet model of short bowel syndrome

Abstract

This study provides evidence of an early and persistent disturbance of the bile acid profile throughout the entero-hepatic circulation with an increase in the proportion of primary bile acids and a decrease in secondary bile acids following SBR. These changes were associated with a loss of bacteria belonging to the Clostridiales order consistent with a disturbance in the bile-microbial axis following SBR.